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Published on: October 27, 2020
[Expression of TGF-beta1 mRNA in prostate carcinoma tissues and its significance]
Ze-liang Li1, Ye Yang, Zhen-hua Li
1Department of Urology, the No. 1 Hospital of China Medical University, Shenyang, Liaoning 110001, China. lizheliang@hotmail.com
Objective:
To investigate the expression of TGF-beta1 mRNA in prostate carcinoma tissues and its significance.
Methods:
RT-PCR method was used to examine the expression of TGF-beta1 mRNA in normal and carcinomatous prostate tissues.
Results:
The relative content of TGF-beta1 mRNA of normal prostate tissues was (0.74 +/- 0.11), while those of carcinomatous prostate tissues at T1-T2 and T3-T4 stages were (0.69 +/- 0.10) and (0.44 +/- 0.08) respectively, with significant difference between T1-T2 and T3-T4 (P < 0.05). And the relative contents of TGF-beta1 mRNA of carcinomatous prostate tissues with Gleason score < or = 5, 6-8 and > or = 9 were (0.70 +/- 0.12), (0.54 +/- 0.11) and (0.42 +/- 0.09) respectively.
Conclusion:
The expression of TGF-beta1 mRNA was negatively correlated with the clinical stage and Gleason score of prostate carcinoma.
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