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Updated: Aug 9, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
[The clinical and pathogenetic aspects of tuberculosis of digestive organs]
Abstract:
Among 126 patients with gastrointestinal tract tuberculosis (GITT), 54.0% of cases developed GITT with involvement of the lung, by preceding the latter in 16.7%; concomitantly with the latter in 13.5%, and by following it in 23.8%; in addition to pulmonary affection, GITT was concurrent with the involvement of other systems in every 4 cases. In 50% of cases, GIIT involved 2 organs or more; lymph nodes in 50.0%, the intestine in 45.2%, the liver in 27.8%; the peritoneum in 23.0% of cases, less frequently the stomach, pancreas, omentum, esophagus, gallbladder. The complications due to GITT were perforation of ulcers of cavitary organs in 64.6%, intestinal bleeding in 33.3%, and ileum in 12.7%. At different sites of GITT, mortality ranged from 12.5 to 85.0% and as a whole it was 58.0%. In tuberculosis of cavitary organs, the risk of death is caused by its complications in 100%, intraabdominal and retroabdominal lymph nodes in a third of cases; in hepatic tuberculosis, the risk of hepatocellular insufficiency was equal to 0.2.
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