[Nosocomial post-neurosurgery meningitis due to Corynebacterium jeikeium]

Sabrina Morosi1, Massimo Marroni, Ada Maristella Egidi

  • 1Clinica delle Malattie Infettive, Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia. sabrinamorosi@hotmail.com

Insights

Rare meningitis caused by Corynebacterium jeikeium occurred in a patient post-neurosurgery without central nervous system devices. This case highlights a unique infection following pituitary tumor removal.

Area of Science:

  • Neuroscience
  • Infectious Diseases
  • Oncology

Background:

  • Post-neurosurgical meningitis is a known complication, though rare.
  • Corynebacterium jeikeium is an opportunistic pathogen typically associated with immunocompromised individuals or device-related infections.

Observation:

  • A 78-year-old patient with chronic myeloproliferative syndrome underwent resection of a pituitary macroadenoma.
  • The patient subsequently developed an acute meningeal syndrome.

Findings:

  • Cultures revealed meningitis caused by Corynebacterium jeikeium.
  • This infection occurred in the absence of any central nervous system devices.

Implications:

  • This case underscores the potential for Corynebacterium jeikeium to cause meningitis in non-device-related post-neurosurgical settings.
  • Highlights the importance of considering unusual pathogens in immunocompromised patients presenting with meningeal symptoms after surgery.

Related Concept Videos

Bacterial Meningitis01:24

Bacterial Meningitis

Bacterial meningitis is a severe infectious disease involving inflammation of the meninges, the protective membranes surrounding the brain and spinal cord. It occurs when pathogenic bacteria cross the blood–brain barrier and enter the cerebrospinal fluid. Common causative organisms include Neisseria meningitidis, Streptococcus pneumoniae, Haemophilus influenzae type b, Listeria monocytogenes, and Escherichia coli K1. The exact route of entry varies by pathogen and host condition.Routes of Entry...
Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Cryptococcal Meningitis01:27

Cryptococcal Meningitis

Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...