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Related Experiment Videos

A randomized crossover trial comparing three plateletpheresis machines.

José Luis Bueno1, Fernando García, Emma Castro

  • 1Blood Donation Center of the Spanish Red Cross, Madrid, Spain. jlbueno@cdscruzroja.infonegocio.com

Transfusion
|August 5, 2005
PubMed
Summary

The Trima Accel is the fastest apheresis machine for platelet collection and preferred by donors. The Amicus Crescendo offers the highest efficiency, while the MCS Plus provides the most accurate processing time measurement.

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Area of Science:

  • Apheresis technology
  • Hematology
  • Transfusion medicine

Background:

  • Platelet (PLT) apheresis is crucial for transfusion support.
  • Optimizing apheresis machine performance is essential for efficient blood collection.

Purpose of the Study:

  • To compare the processing time and donor acceptance of three apheresis machines: Amicus Crescendo, MCS Plus, and Trima Accel.
  • To evaluate efficiency, adverse reactions, yield, leukodepletion, and machine accuracy.

Main Methods:

  • A randomized crossover trial involving 51 donors.
  • Comparison of processing times for a standard 3.5 x 10(11) PLT dose (TSD3.5).
  • Statistical analysis using generalized estimating equations to account for non-independent measurements.

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Main Results:

  • Trima Accel had the shortest TSD3.5 (47.9 min), followed by Amicus Crescendo (60.3 min) and MCS Plus (66.7 min) (p < 0.0001).
  • Amicus Crescendo showed the highest efficiency (87.5%), and MCS Plus offered superior leukodepletion.
  • Donors preferred Accel (61%) over Amicus (35%) and MCS Plus (4%), valuing processing speed.

Conclusions:

  • Trima Accel is the fastest apheresis machine, leading to higher donor preference.
  • Amicus Crescendo is the most efficient machine.
  • MCS Plus accurately measures processing time and offers robust leukodepletion.