Related Experiment Video
Updated: Aug 16, 2026
Senescence Detection Using Reflected Light in Adipose Stromal Vascular Fraction
Published on: June 5, 2026
Alteration of leptin-induced STAT3 activation in the brain of senescence-accelerated mouse (SAM) P8
Toru Hosoi1, Yasunobu Okuma, Atsushi Ono
1Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-ku, Sapporo 060-0812, Japan.
Abstract:
We used senescence-accelerated mouse prone 8 (SAMP8), a useful model of accelerated aging, to investigate the responsiveness to leptin with aging. The state of leptin-induced STAT3 phosphorylation in the hypothalamus was found to be higher in SAMP8 than in SAMR1, a control mouse showing normal aging, at 14-18 months of age but not at 2 months of age. Moreover, leptin receptor Ob-Rb expression in the hypothalamus was up-regulated in SAMP8. The results indicate that leptin sensitivity increases with aging in the SAM mouse brain.