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Published on: March 10, 2015
Evaluation of Strychnos pseudoquina ST. HIL. leaves extract on gastrointestinal activity in mice
Marcelo Aparecido da Silva1, Bruna Paola Murino Rafacho, Clelia Akiko Hiruma-Lima
1Departamento de Química Orgânica, Instituto de Química, c.p. 355, CEP 14800-900, UNESP, Araraquara, SP, Brazil.
Abstract:
Strychnos pseudoquina ST. HIL. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects.