Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Speech, cognitive, and behavioral outcomes in nonsyndromic craniosynostosis.

Devra B Becker1, Jason D Petersen, Alex A Kane

  • 1The Cleft Palate and Craniofacial Deformities Institute, Department of Pediatric Psychology, St. Louis Children's Hospital, St. Louis, MO, USA.

Plastic and Reconstructive Surgery
|August 5, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative Outcomes and Morphology Following Surgical Reconstruction for Mercedes Benz Craniosynostosis.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2026
Same author

Outcomes Amidst Adversity: Socioeconomic Factors in Cleft Lip and Palate Care in the Southern United States.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2026
Same author

Incidence of Velopharyngeal Insufficiency Surgery Following Orthognathic Surgery in Cleft Lip and Palate.

The Journal of craniofacial surgery·2026
Same author

Incidence of Psychological and Neurodevelopmental Disorders in Craniosynostosis.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2026
Same author

External Fixation for Ballistic Mandibular Trauma: An Old Method for a Modern Problem.

Annals of plastic surgery·2026
Same author

Craniofacial Symmetry Progression Following Strip Craniectomy Versus Fronto-Orbital Advancement in Unilateral Coronal Synostosis.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2026
Same journal

"Inferior Repositioning of the High-Riding Nipple Using a Parenchymal-Based Flap".

Plastic and reconstructive surgery·2026
Same journal

A Four-Step Strategy for the Treatment of Facial Rhytids: A Focus on Upper Facial Wrinkles.

Plastic and reconstructive surgery·2026
Same journal

Evaluating Long-Term Retention of Fresh-Frozen Costal Cartilage Allograft in An Animal Model.

Plastic and reconstructive surgery·2026
Same journal

Manual extrusion of fat granules for primary thinning of a bulky flap.

Plastic and reconstructive surgery·2026
Same journal

"Impact of regional surgeon competition on use and costs of carpal tunnel releases".

Plastic and reconstructive surgery·2026
Same journal

Prevention of Tendon Adhesion and Preservation of Healing Strength Using a Hydrophobically Modified Alaska Pollock Gelatin Sheet.

Plastic and reconstructive surgery·2026
See all related articles

Nonsyndromic craniosynostosis is frequently linked to speech, cognitive, and behavioral issues. The prevalence of these abnormalities increases with age, highlighting the need for ongoing assessment and intervention.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Pediatric Medicine

Background:

  • The neuropsychological impact of nonsyndromic craniosynostosis remains poorly understood.
  • This condition involves the premature fusion of skull sutures without associated genetic syndromes.
  • Existing research has not fully elucidated the spectrum of neurodevelopmental outcomes.

Purpose of the Study:

  • To determine the prevalence of speech-language, cognitive, and behavioral abnormalities in patients with nonsyndromic craniosynostosis.
  • To analyze how these abnormalities vary based on the specific suture fused and the age at diagnosis.
  • To provide data for improved clinical management and understanding of this condition.

Main Methods:

  • Retrospective chart review of patients diagnosed with nonsyndromic craniosynostosis between 1978 and 2000.

Related Experiment Videos

  • Documentation of diagnosed speech-language, cognitive, or behavioral abnormalities.
  • Statistical analysis to identify correlations between affected sutures, age, and abnormality prevalence.

    • Main Results:

    • 49% of 214 evaluated patients exhibited speech, cognitive, and/or behavioral abnormalities.
    • Abnormality rates varied by suture: right unilateral coronal (61%), metopic (57%), bilateral coronal (55%), left unilateral coronal (52%), multiple sutures (47%), lambdoid (44%), and sagittal (39%).
    • A statistically significant increase in abnormality prevalence was observed compared to the general population, with higher rates in older children.

    Conclusions:

    • Nonsyndromic craniosynostosis is commonly associated with cognitive, speech, and behavioral deficits.
    • The underlying causes for this association are currently unknown.
    • The increased diagnosis of cognitive and behavioral dysfunction with age underscores the necessity for continuous monitoring and therapeutic interventions.