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Updated: Jul 24, 2026
09:30
Phosphopeptide Analysis of Rodent Epididymal Spermatozoa
Published on: December 30, 2014
Phosphodiesterase 11 (PDE11): is it a player in human testicular function?
1Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, USA. sharron.francis@vanderbilt.edu
International Journal of Impotence Research
|August 5, 2005
Summary
Tadalafil
Area of Science:
- Pharmacology
- Molecular Biology
Background:
- Phosphodiesterase 11 (PDE11) is a recently identified enzyme family member.
- Four splice variants (PDE11A1-4) have been identified, with specific tissue distributions suggested for PDE11A3 (testis) and PDE11A4 (prostate).
- Tadalafil's inhibition of PDE11A is a subject of ongoing debate.
Purpose of the Study:
- To review the controversy surrounding tadalafil's inhibition of phosphodiesterase 11 (PDE11).
- To discuss recent findings and their implications for PDE11 inhibition by tadalafil.
Main Methods:
- Review of existing literature on PDE11 and tadalafil.
- Analysis of recent studies investigating the effects of tadalafil on PDE11 and related physiological parameters.
Main Results:
- Previous studies suggested tadalafil's inhibition of PDE11 in the testis might not have adverse clinical effects.
- Daily tadalafil administration in healthy volunteers did not alter semen or hormonal parameters.
- Recent publications have reignited the debate regarding tadalafil's impact on PDE11.
Conclusions:
- The clinical significance of tadalafil's PDE11 inhibition remains a contested topic.
- Further research and expert perspective are needed to fully understand the implications of PDE11 inhibition by tadalafil.
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