Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stem cell biology for vascular regeneration.

T Asahara1

  • 1Riken Center for Developmental Biology, Kobe, Japan. asa777@aol.com

Ernst Schering Research Foundation Workshop
|August 6, 2005
PubMed
Summary

Endothelial progenitor cells (EPCs) from bone marrow are key to new blood vessel formation in adults. These cells can be used therapeutically for regenerative medicine and treating vascular diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimization of the reconstruction kernel for temporal bone imaging using photon-counting detector CT: A combined physical and visual evaluation.

Radiography (London, England : 1995)·2025
Same author

Impact of pre-reconstruction filtering with butterworth filter on <sup>111</sup>In-pentetreotide SPECT image quality and quantitative accuracy: A phantom study.

Radiography (London, England : 1995)·2025
Same author

Angiogenic conditioning of peripheral blood mononuclear cells promotes fracture healing.

Bone & joint research·2017
Same author

Impaired development and dysfunction of endothelial progenitor cells in type 2 diabetic mice.

Diabetes & metabolism·2016
Same author

Randomized clinical trial of the effect of perioperative synbiotics versus no synbiotics on bacterial translocation after oesophagectomy.

The British journal of surgery·2014
Same author

Alteration of telomeric repeat length in hepatocellular carcinoma is independent of telomerase activity.

International journal of oncology·2011

Area of Science:

  • Regenerative Medicine
  • Vascular Biology
  • Stem Cell Research

Background:

  • Bone marrow-derived endothelial progenitor cells (EPCs) are crucial for neovascularization in adults.
  • EPCs contribute to both physiological and pathological neovascularization processes.
  • The concept of vasculogenesis, previously known in embryonic development, is now recognized in adult vascular organogenesis.

Purpose of the Study:

  • To provide an updated overview of endothelial progenitor cell (EPC) biology.
  • To explore the therapeutic potential of EPCs in regenerative medicine.
  • To highlight the role of EPCs in pathological neovascularization.

Main Methods:

  • Review of current literature on EPC biology and function.
  • Analysis of studies investigating EPC homing and differentiation.
  • Examination of preclinical and clinical data on EPC-based therapies.

Main Results:

  • EPCs isolated from bone marrow (BM) play a pivotal role in adult neovascularization.
  • EPCs demonstrate the ability to home to sites of vascular damage and differentiate into endothelial cells (ECs).
  • EPCs hold significant promise as therapeutic agents for promoting neovascularization in pathological conditions.

Conclusions:

  • Endothelial progenitor cells (EPCs) are vital for adult neovascularization and vascular repair.
  • EPC biology is a rapidly advancing field with substantial implications for regenerative medicine.
  • Therapeutic applications of EPCs offer a promising avenue for treating vascular diseases and promoting tissue regeneration.

Related Experiment Videos