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Updated: Aug 16, 2026

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
Published on: March 18, 2015
Stem cell biology for vascular regeneration
1Riken Center for Developmental Biology, Kobe, Japan. asa777@aol.com
Abstract:
The isolation of endothelial progenitor cells (EPCs) derived from bone marrow (BM) was one epoch-making event for the recognition of neovessel formation in adults occurring as physiological and pathological responses. The finding that EPCs home to sites of neovascularization and differentiate into endothelial cells (ECs) in situ is consistent with vasculogenesis, a critical paradigm that has been well described for embryonic neovascularization, but proposed recently in adults in which a reservoir of stem or progenitor cells contribute to vascular organogenesis. EPCs have also been considered as therapeutic agents to supply the potent origin of neovascularization under pathological conditions. This chapter highlights an update of EPC biology as well as its potential use for therapeutic regeneration.
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