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Angiogenesis in oral squamous cell carcinoma
G Ascani1, P Balercia, M Messi
1Department of Maxillofacial Surgery, Torrette Regional Hospital, Ancona, Italy. g.ascani@inwind.it
Summary
Microvessel density is a significant prognostic factor in oral squamous cell carcinoma. Higher microvessel density correlates with advanced tumor grade and lymph node metastasis, indicating a poorer prognosis.
Area of Science:
- Oncology
- Pathology
- Cancer Research
Background:
- Microvessel density (MVD) is a recognized prognostic indicator in various primary tumors.
- Increased MVD in oral tumors suggests a role for angiogenesis in disease progression and poor prognosis.
Purpose of the Study:
- To evaluate microvessel density in oral squamous cell carcinoma (OSCC).
- To investigate correlations between MVD and clinico-pathological parameters in OSCC.
Main Methods:
- Immunohistochemical analysis using anti-CD34 monoclonal antibody on 64 OSCC cases.
- Statistical analysis of MVD against parameters including age, sex, tumor site, size, TNM stage, and histological grading.
Main Results:
- Microvessel density significantly differed across histological grades (G1, G2, G3) (p = 0.0331).
- MVD was significantly higher in node-positive patients compared to node-negative patients (p < 0.0001).
- No statistical correlation was found between MVD and age, sex, tumor site, or size.
Conclusions:
- Microvessel density is a valuable prognostic marker in oral squamous cell carcinoma.
- Angiogenesis, indicated by MVD, plays a crucial role in the progression and prognosis of OSCC, particularly concerning lymph node metastasis.