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Related Experiment Videos

Cyclooxygenase-2 expression in brain metastases.

Aftab Karim1, Marjorie Fowler, Lamar Jones

  • 1Department of Neurosurgery, LSU Health Sciences Center, Shreveport, LA 71130, USA.

Anticancer Research
|August 6, 2005
PubMed
Summary

Cyclooxygenase-2 (COX-2) expression in brain metastases did not correlate with tumor type, necrosis, or radiation resistance. COX-2 is not consistently expressed in these metastases.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Elevated Cyclooxygenase-2 (COX-2) expression is linked to increased tumor metastatic potential.
  • COX-2 expression also correlates with radiation resistance across various tumor types.

Purpose of the Study:

  • To investigate the correlation between COX-2 expression and metastatic tumor type or necrosis.
  • To compare COX-2 expression in radiation-resistant (renal cell, melanoma) versus radiation-sensitive (breast, lung) tumors.

Main Methods:

  • Analysis of COX-2 expression in brain metastasis specimens from 16 patients using an antibody-based immunoassay.
  • Specimens included metastases from lung, breast, melanoma, and renal cell carcinomas.
  • Assessment for the presence or absence of necrosis in all specimens.

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Main Results:

  • Ten of sixteen brain metastasis specimens exhibited 10% or less COX-2 immunostaining.
  • No statistically significant correlation was found between COX-2 immunostaining and metastatic tumor type or necrosis.
  • Renal cell carcinoma and melanoma showed variable COX-2 expression.

Conclusions:

  • COX-2 expression is not consistently found in brain metastases.
  • The level of COX-2 expression does not correlate with metastatic tumor type or necrosis.
  • No significant difference in COX-2 expression was observed between radioresistant and radiosensitive tumors in this study.