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Updated: Aug 16, 2026
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
Phase II study of docetaxel plus cisplatin as a second-line combined therapy in patients with advanced gastric
Chikara Kunisaki1, Toshio Imada, Roppei Yamada
1Department of Surgery, Gastroenterological Center, Yokohama City University, Graduate School of Medicine, Yokohama, Japan. s0714@med.yokohama-cu.ac.jp
Background:
We conducted a pilot phase II study to evaluate the efficacy and safety of docetaxel and cisplatin as a combination second-line therapy for advanced gastric cancer.
Patients And Methods:
Between 2000 and 2003, 30 patients were enrolled into this study. Chemotherapy consisted of 60 mg/m2 of docetaxel followed by 60 mg/m2 of cisplatin. This regimen was repeated at least three times at 3-week intervals.
Results:
The overall response rate was 26.7%. The median time to disease progression was 4.5 months. The median survival time was 13 months from the start of the first-line therapy and 6 months from the second-line therapy. With respect to toxicity, the major adverse effect was leukopenia, which reached grades 3-4 in 26.7%. Non-hematological toxicities were usually moderate, and no deaths were attributable to the adverse effects of the drugs.
Conclusion:
This combination therapy was effective as a second-line treatment for advanced gastric cancer with acceptable toxic side-effects.
