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Updated: Aug 16, 2026
An In Vitro System to Study Tumor Dormancy and the Switch to Metastatic Growth
Published on: August 11, 2011
Trauma-associated growth of suspected dormant micrometastasis
Nagi S El Saghir1, Ihab I Elhajj, Fady B Geara
1Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon. nagi.saghir@aub.edu.lb
Background:
Cancer patients may harbor micrometastases that remain dormant, clinically undetectable during a variable period of time. A traumatic event or surgery may trigger the balance towards tumor growth as a result of associated angiogenesis, cytokine and growth factors release.
Case Presentation:
We describe a patient with non-small lung cancer who had a rapid tumor growth and recurrence at a minor trauma site of his skull bone.
Conclusion:
This case is an illustration of the phenomenon of tumor growth after trauma or surgery and its associated cellular mechanisms. This phenomenon deserves further investigation and study.
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