Related Experiment Video
Updated: Aug 16, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
Published on: January 26, 2024
[Expression of extracellular matrix metalloproteinase inducer during normal pregnancy]
Yong-qing Wang1, Jun Li, Tao Shang
1Department of Obstetrics and Gynecology, the Second Hospital of China Medical University, Shenyang 110003, China.
Objective:
To study the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) during normal pregnancy.
Methods:
The expression of EMMPRIN was studied with immunohistochemistry in normal pregnancy.
Results:
The expression of EMMPRIN was obvious, and appeared mainly on membrane of cytotrophoblast, syncytiotrophoblast, cytotrophoblast column of the villi of gestational weeks 6 to 9, mid-term and term placenta and extravillous cytotrophoblast of deciduas of mid-term and term placenta. The expression reached a peak level at gestational week 6 and gradually decreased from week 7 and stabilized to a low level at mid-term and term placenta when the expression of extravillous cytotrophoblast of deciduas was increased.
Conclusion:
EMMPRIN may be an important factor for implantation during early pregnancy and participate in maintaining gestation during mid-term and term pregnancy.
Related Concept Videos
Role of Matrix Metalloproteases in Degradation of ECM
A...
The Extracellular Matrix
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
The Extracellular Matrix
Extracellular Matrix
The Tumor Microenvironment
Regulation of Angiogenesis and Blood Supply
