Elevated TFPI levels in female hyperhomocysteinemic patients
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Updated: Aug 16, 2026
Extracellular Vesicle Tissue Factor Activity Assay
Published on: December 29, 2023
Elmar Thyzel1, Sabine Siegling, Christian Götting
1Institut für Laboratoriums- und Transfusionsmedizin, Herz- und Diabeteszentrum Nordrhein-Westfalen, Universitätsklinik der Ruhr-Universität Bochum, Bad Oeynhausen, Germany.
Objectives:
Hyperhomocysteinemia is a risk factor for cardiovascular diseases, while tissue factor pathway inhibitor (TFPI) regulates the extrinsic pathway of blood coagulation. We investigated the in vivo influence of elevated homocysteine concentrations on TFPI levels.
Methods:
Total TFPI levels of 82 hyperhomocysteinemic patients were determined.
Results:
The patients' TFPI levels were significantly elevated compared to blood donors, with a more pronounced effect in females than in males.
Conclusions:
We have shown a gender-dependent TFPI elevation in hyperhomocysteinemic patients.
