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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
[Intracerebral hemorrhage and its sequelae in high risk newborn infants in relation to oxygen deficiency status]
H T Abel1, F Kleinhans, W Lamme
1Frühgeborenenzentrum, Medizinischen Akademie Magdeburg.
Abstract:
In a prospective study 325 risk newborn infants were examined by means of ultrasound scanning. Children with and without intracerebral haemorrhages were classified, according to pre-, intra-, and postnatal periods of oxygen privation. For the characterization of short-term hypoxia the blood-gas analysis was used for the ascertainment of longtime hypoxia the erythrocytic-density-test (EDT). In dependence on PO2-values less than or equal to 5 kPa intracerebral haemorrhages of variable states increased significantly (p = 0.01). Evaluating the results of erythrocytic-density-test it may be concluded that the prenatal hypoxia has the greatest influence on the rate of intracerebral bleedings. Thus only 37.5% of our patients with prenatal hypoxia remained free of haemorrhages, in contrast of 70.2% of children without deficiency of oxygen.
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