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Chagas disease is an independent risk factor for stroke: baseline characteristics of a Chagas Disease cohort

Jamary Oliveira-Filho1, Leila C Viana, Rodrigo M Vieira-de-Melo

  • 1Cardiomyopathy Clinic, Hospital Universitário Professor Edgard Santos, Federal University of Bahia, Brazil. jamaryof@ufba.br

Stroke
|August 6, 2005
PubMed

Insights

Chagas disease (CD) significantly increases stroke risk in endemic regions. Cardioversion and diabetes also emerged as independent predictors of stroke in cardiopathy patients.

Area of Science:

  • Cardiology
  • Neurology
  • Infectious Diseases

Background:

  • Chagas disease (CD) is a significant cause of cardiopathy in South America.
  • CD is frequently linked to cardioembolic stroke.
  • Understanding stroke predictors in CD is crucial for prevention.

Purpose of the Study:

  • To identify predictors of stroke in patients with Chagas disease.
  • To assess the independent contribution of CD to stroke risk.

Main Methods:

  • A cohort of 305 cardiopathy patients was analyzed.
  • Univariable and multivariable logistic regression models were used.
  • Predictors of stroke were identified and quantified.

Main Results:

  • Stroke occurred more frequently in CD patients (15.0%) than in others (6.3%).
  • Independent predictors of stroke included Chagas disease (OR, 1.09), cardioversion (OR, 1.07), and diabetes (OR, 1.12).
  • Previous diabetes and use of amiodarone and warfarin were also significant in univariable analysis.

Conclusions:

  • Chagas disease is an independent risk factor for stroke.
  • Stroke risk in CD is elevated, irrespective of systolic dysfunction or arrhythmias.
  • These findings highlight the importance of stroke risk assessment in CD patients.
Abstract

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