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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

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Published on: May 15, 2019

Proteasome inhibitors-mediated TRAIL resensitization and Bik accumulation

Hongbo Zhu1, Wei Guo, Lidong Zhang

  • 1Department of Surgical Oncology, Sir Run Run Shaw Hospital, Zhejiang University, China.

Cancer Biology & Therapy
|August 6, 2005
PubMed
Summary

Proteasome inhibitors resensitize cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) therapy. Bik accumulation is critical for this resensitization, enhancing TRAIL-mediated apoptosis.

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