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The Citrobacter rodentium Mouse Model: Studying Pathogen and Host Contributions to Infectious Colitis
Published on: February 19, 2013
Enteric fever-like illness caused by infection with citrobacter amalonaticus
Kanitta Suwansrinon1, Henry Wilde, Visith Sitprija
1Queen Saovabha Memorial Institute, Thai Red Cross Society, 1871 Rama IV Rd, Bangkok, 10330, Thailand. sukanitta@yahoo.com
Abstract:
'Enteric fever' is a potentially fatal, severe systemic disease, which is encountered worldwide. Traditionally, enteric fever refers to a bacteremic illness caused by members of certain Salmonella serotypes, notably: Salmonella typhi, a Gram-negative bacterium, and to a lesser extent, Salmonella paratyphi A, B and C. In addition, other non-salmonella organisms may produce a syndrome clinically indistinguishable from "enteric fever". Brucella sp., Campylobacter sp., Edwardsiella tarda, Enterobacter Cloacae, Escherichia coli, Klebsiella pneumoniae, Providencia alcalifaciens, Pseudomonas sp., Serratia marcescens, Francisella sp. and Yersinia pp have been identified in enteric fever This is, to the best of the authors' knowledge, the first case of Citrobacter to be reported presenting as enteric fever in a normal host in Thailand.
Insights
This study reports the first case of Citrobacter presenting as enteric fever in an otherwise healthy individual in Thailand. This finding expands the known causes of enteric fever beyond Salmonella species.
Area of Science:
- Infectious Diseases
- Microbiology
- Clinical Medicine
Background:
- Enteric fever is a severe systemic illness caused by Salmonella serotypes like Salmonella typhi and Salmonella paratyphi.
- Other non-Salmonella bacteria can also cause symptoms indistinguishable from enteric fever.
- The differential diagnosis of enteric fever includes various bacterial pathogens.
Observation:
- This report details a case of enteric fever in a healthy host in Thailand.
- The causative agent identified was Citrobacter, a bacterium not previously associated with enteric fever in this demographic.
- This marks the first documented instance of Citrobacter causing enteric fever in a normal host in Thailand.
Findings:
- Citrobacter species can present clinically as enteric fever.
- The case highlights the importance of considering a broader range of pathogens in enteric fever diagnosis.
- This expands the etiological spectrum of enteric fever.
Implications:
- Clinicians should consider Citrobacter in the differential diagnosis of enteric fever, especially in endemic regions.
- This case may prompt further research into the role of Citrobacter in causing systemic infections.
- Understanding the diverse causes of enteric fever is crucial for effective treatment and public health strategies.
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