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Hyperprolactinemia after laparoscopic ovarian drilling: an unknown phenomenon
Mohammad E Parsanezhad1, Saeed Alborzi, Jaleh Zolghadri
1Division of infertility and GYN endocrinology, Department of Obstetrics and Gynecology, Medical School, Shiraz University of Medical sciences, Shiraz, Iran. parsame@sums.ac.ir
Reproductive Biology and Endocrinology : RB&E
|August 9, 2005
Summary
Ovarian drilling in women with polycystic ovary syndrome (PCOS) can lead to elevated prolactin levels, potentially causing anovulation. Monitoring prolactin is recommended for patients experiencing persistent anovulation after the procedure.
Area of Science:
- Reproductive Endocrinology
- Gynecology
- Infertility Research
Background:
- Ovarian drilling is a known intervention for polycystic ovary syndrome (PCOS).
- Previous studies focused on gonadotropin and androgen levels post-ovarian drilling.
- The impact of ovarian drilling on prolactin and ovulation in PCOS requires further investigation.
Purpose of the Study:
- To evaluate the effect of ovarian drilling on serum prolactin levels in women with PCOS.
- To assess the relationship between prolactin levels and ovulation post-ovarian drilling in PCOS patients.
Main Methods:
- Prospective controlled study involving 36 women with PCOS undergoing ovarian electrocauterization.
- Control group comprised 35 ovulatory women with unexplained infertility.
- Hormonal assessments (including prolactin, LH, testosterone, progesterone) and folliculometry were performed pre- and post-procedure.
Main Results:
- Serum prolactin levels significantly increased 6-10 weeks post-ovarian drilling in the PCOS group (P=0.011).
- No significant change in prolactin levels was observed in the control group (P=0.981).
- Elevated prolactin levels correlated with persistent anovulation in 73.2% of PCOS patients post-procedure.
Conclusions:
- Hyperprolactinemia following ovarian cauterization may contribute to anovulation in PCOS patients.
- The exact cause of post-procedural hyperprolactinemia remains unknown.
- Hormonal assessment, particularly prolactin, is recommended for anovulatory PCOS patients after ovarian cauterization.