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Published on: February 10, 2015
[The relationship between the C589T polymorphism of IL-4 gene and cholelithiasis]
Xiao-ming Zhuang1, Hong Xiao, Yuan Zhang
1Department of General Surgery, Affiliated Drum Tower Hospital of Medical College of Nanjing University, Nanjing 210008, China.
Objective:
To investigate the relationship between IL-4 gene polymorphism and cholelithiasis in Chinese population.
Methods:
Polymerase chain reaction combined with restriction enzyme digestion was used to detect the polymorphism of IL-4 gene in 81 cholecystolithiasis, 41 patients with biliary duct stone.
Results:
There were no significant differences of the IL-4 gene polymorphism genotypes and alleles between 81 cholecystolithiasis patients (CC11.1%, CT34.6%, TT54.3%; C28.4.7%, T71.6%). There were significant differences of the IL-4 gene polymorphism genotypes and alleles between 41 patients with biliary duct stone (CC48.8%, CT36.6%, TT14.6%; C67.1%, T32.9%).
Conclusions:
The C589T polymorphism of IL-4 gene was not associated with cholecystolithiasis patients in Chinese, but was related to patients with biliary duct stone in Chinese.
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