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Differences in keratoconus as a function of gender.

Barbara A Fink1, Heidi Wagner, Karen Steger-May

  • 1The Ohio State University College of Optometry, 338 West Tenth Avenue, Columbus OH 43210-1240, USA.

American Journal of Ophthalmology
|August 9, 2005
PubMed
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Gender differences in keratoconus (KC) patients were identified. Women reported more symptoms and near work, while men had better visual acuity in multivariate models, highlighting distinct patient profiles.

Area of Science:

  • Ophthalmology
  • Corneal Diseases
  • Keratoconus Research

Background:

  • Keratoconus (KC) is a progressive thinning of the cornea.
  • Understanding patient demographics and experiences is crucial for management.
  • The Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study provides extensive data on KC patients.

Purpose of the Study:

  • To investigate and characterize gender-specific differences in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study cohort.
  • To identify variations in patient history, visual function, and ocular symptoms between men and women with keratoconus.

Main Methods:

  • An observational, longitudinal study design was employed.
  • Data from 1209 subjects across 16 clinics were analyzed.

Related Experiment Videos

  • Multivariate regression models (linear and logistic) were used to assess gender differences in baseline characteristics, controlling for age, race, education, and corneal curvature.

    • Main Results:

    • Women were older, more likely to have a family history of KC, more likely to be nonwhite, and less educated than men.
    • Vogt's striae and high-contrast visual acuity were the only visual characteristics differing between genders in multivariate analysis.
    • Women reported more ocular symptoms, particularly dryness, engaged in more near work, and had greater difficulty with distance activities and driving.

    Conclusions:

    • Significant gender differences exist in the patient history, reported ocular symptoms, and visual function of individuals with keratoconus.
    • These findings underscore the importance of considering gender in the comprehensive evaluation and management of keratoconus patients.