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Updated: Aug 16, 2026
Preparation and Evaluation of 99mTc-labeled Tridentate Chelates for Pre-targeting Using Bioorthogonal Chemistry
Published on: February 4, 2017
Characterisation and biodistribution of two neutral 99mTc(CO)3 complexes with a tridentate ligand
Dirk Rattat1, Bernard Cleynhens, Guy Bormans
1Laboratory for Radiopharmaceutical Chemistry and Nuclear Medicine, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium.
Abstract:
N-(2-Mercapto-propyl)-1,2-phenylenediamine (MPPDA) and N-beta-aminoethylglycine (AEG) were labelled with 99mTc(CO)3(+) to form the neutral complexes [99mTc(CO)3(MPPDA)] and [99mTc(CO)3(AEG)]. Both complexes were formed in excellent yields and their identity was confirmed by LC-MS. In mice, none of the new tracer agents showed brain uptake. [(99m)Tc(CO)3(MPPDA)] was trapped mainly in the liver and excreted via the hepatobiliary system, whereas [99mTc(CO)3(AEG)] was excreted rapidly via the kidneys to the urine.
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