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Inflammation and coronary artery disease

Alice Y Tiong1, David Brieger

  • 1Department of Cardiology, Concord Repatriation General Hospital, Sydney, Australia. atio5782@mail.usyd.edu.au

American Heart Journal
|August 9, 2005
PubMed

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Overview
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The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...