Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Frailty, morbidity and survival.

Barbara E K Klein1, Ronald Klein, Michael D Knudtson

  • 1Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 405 WARF, Madison, WI 53726-2336, USA. kleinb@epi.ophth.wisc.edu

Archives of Gerontology and Geriatrics
|August 9, 2005
PubMed
Summary

Measures of frailty, like gait speed and handgrip strength, are linked to increased disease risk and poorer survival in older adults. This study highlights frailty as a key predictor of health outcomes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exome-Wide Analysis Identifies a Rare <i>EXD3</i> Missense Variant Associated With Diabetic Kidney Disease.

Kidney international reports·2026
Same author

Diabetes and incident stroke and mediation by microvascular dysfunction: Pooled analysis of three population-based studies.

Diabetes, obesity & metabolism·2025
Same author

Genetics of C-Peptide and Age at Diagnosis in Type 1 Diabetes.

Diabetes·2024
Same author

Association of macular pigment optical density with retinal layer thicknesses in eyes with and without manifest primary open-angle glaucoma.

BMJ open ophthalmology·2023
Same author

Association of fractal dimension and other retinal vascular network parameters with cognitive performance and neuroimaging biomarkers: The Multi-Ethnic Study of Atherosclerosis (MESA).

Alzheimer's & dementia : the journal of the Alzheimer's Association·2023
Same author

OMEGA-3 FATTY ACIDS ARE ASSOCIATED WITH DECREASED PRESENCE AND SEVERITY OF DIABETIC RETINOPATHY: A Combined Analysis of MESA and GOLDR Cohorts.

Retina (Philadelphia, Pa.)·2023

Area of Science:

  • Gerontology
  • Public Health
  • Clinical Medicine

Background:

  • Frailty, characterized by decreased physical reserve, is distinct from disability and disease burden.
  • Population-based studies are crucial for understanding frailty's impact on health outcomes.

Purpose of the Study:

  • To investigate the association between frailty markers and disease outcomes, including survival.
  • To evaluate the predictive value of frailty in a Midwestern adult population.

Main Methods:

  • Assessed frailty using gait-time, handgrip strength, respiratory flow rate, chair stand ability, and visual acuity.
  • Collected data from the Beaver Dam Eye Study cohort (n=2962) between 1998-2000.
  • Followed participants for mortality up to 4.12 years, adjusting for age, sex, and comorbidities.

Related Experiment Videos

Main Results:

  • Frailty markers were significantly associated with age.
  • A composite frailty index (0-5) showed greater frailty was linked to cardiovascular disease and hypertension.
  • Increased frailty independently predicted poorer survival and higher likelihood of concurrent medical conditions.

Conclusions:

  • Frailty is a significant predictor of adverse health outcomes, including mortality.
  • Functional measures of frailty are valuable for assessing health risks in older adults.
  • Early identification and management of frailty may improve long-term survival and quality of life.