Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cellular interactions with elastin.

Ursula R Rodgers1, Anthony S Weiss

  • 1School of Molecular and Microbial Biosciences, University of Sydney, NSW, Australia.

Pathologie-Biologie
|August 9, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Grafts in tendon repair.

Materials today. Bio·2026
Same author

Bioprinting vascularized skin analogs: a stepwise approach.

Burns & trauma·2025
Same author

Sheep femoral artery occlusion is well tolerated and does not result in ischemia.

Animal models and experimental medicine·2025
Same author

Rapid closure and hemostasis of ruptured soft tissues using a modified human tropoelastin-based sealant in preclinical models.

Science translational medicine·2025
Same author

Corrigendum to "Engineering a sprayable and elastic hydrogel adhesive with antimicrobial properties for wound healing" [Biomaterials 139 (2017), 18080].

Biomaterials·2024
Same author

Perspectives on Recent Developments and Directions in Tissue Engineering and Regenerative Medicine.

Tissue engineering. Part A·2024
Same journal

Pathologie-biologie·2020
Same journal

Antibacterial and antibiofilm activities of Laurus nobilis L. essential oil against Staphylococcus aureus strains associated with oral infections.

Pathologie-biologie·2015
Same journal

[Not Available].

Pathologie-biologie·2015
Same journal

Oxidative damage and histopathological changes in lung of rat chronically exposed to nicotine alone or associated to ethanol.

Pathologie-biologie·2015
Same journal

Biological diagnosis of diabetes mellitus.

Pathologie-biologie·2015
Same journal

Association of CagPAI integrity with severeness of Helicobacter pylori infection in patients with gastritis.

Pathologie-biologie·2015
See all related articles

Elastin and its precursor, tropoelastin, are vital for tissue elasticity and influence cell behavior. This study explores how cell-surface receptors mediate these crucial elastin-cell interactions.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Extracellular Matrix Research

Background:

  • Elastin is a critical extracellular matrix protein providing elasticity to tissues like the aorta and lungs.
  • Tropoelastin is the soluble precursor to elastin.
  • Elastin, tropoelastin, and their degradation products modulate cell functions including chemotaxis, proliferation, and adhesion.

Purpose of the Study:

  • To investigate the mechanisms of cell-elastin interactions.
  • To identify and discuss the cell-surface receptors involved in mediating cellular responses to elastin and tropoelastin.
  • To focus on the role of these receptors in elastin formation.

Main Methods:

  • Literature review and synthesis of existing research on elastin biology and cell signaling.

Related Experiment Videos

  • Analysis of studies identifying elastin-binding proteins and receptors.
  • Discussion of signaling pathways involving identified receptors.

    • Main Results:

    • Elastin-cell interactions are mediated by multiple receptors, not solely the elastin receptor.
    • G protein-coupled receptors and integrins play significant roles in cell-elastin communication.
    • These receptors are implicated in cellular responses triggered by elastin and its precursors.

    Conclusions:

    • Cell-surface receptors, including GPCRs and integrins, are key mediators of elastin-cell interactions.
    • Understanding these receptor roles is crucial for elucidating elastin formation and its biological functions.
    • Further research into these interactions can inform therapeutic strategies related to elastic tissues.