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Updated: Aug 16, 2026

Comparative Analysis of Human Growth Hormone in Serum Using SPRi, Nano-SPRi and ELISA Assays
Published on: January 7, 2016
Diagnostic and therapeutic advances in growth hormone insensitivity
Alessia David1, Louise A Metherell, Adrian J L Clark
1Molecular Endocrinology Centre, William Harvey Research Institute, St. Bartholomew's Hospital, London, UK.
Abstract:
Diagnostic and therapeutic advances in growth hormone insensitivity (GHI) have occurred principally in two areas: the molecular characterization of patients with GHI and treatment with recombinant human insulin like growth factor-I (IGF-I). This article discusses the current status of molecular diagnosis across the spectrum of the disorder. Treatment with recombinant human IGF-I in classical cases is summarized, and potential new targets for treatment are discussed together with the potential for therapy using the newly developed compound recombinant human IGF-I/IGF binding protein-3.
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