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Updated: Jul 16, 2026
07:27
Olfactory Assays for Mouse Models of Neurodegenerative Disease
Published on: August 25, 2014
Modern psychophysical tests to assess olfactory function
A Eibenstein1, A B Fioretti, C Lena
1Surgical Sciences Department, ENT, University of L'Aquila, Piazza S. Tommasi 1, I-67100, L'Aquila, Italy.
Summary
Olfactory tests can aid in diagnosing neurodegenerative diseases like Parkinson's and Alzheimer's, as smell dysfunction often precedes other symptoms. An ENT evaluation is recommended before administering these tests.
Area of Science:
- Neuroscience
- Otorhinolaryngology
Background:
- The sense of smell is crucial for quality of life.
- Olfactory disorders can stem from airway inflammation or neurodegenerative conditions.
- Reduced sense of smell (hyposmia) may indicate early stages of Parkinson's and Alzheimer's disease.
Purpose of the Study:
- To review modern olfactory tests and their clinical applications.
- To highlight the diagnostic value of olfactory testing in neurodegenerative diseases.
Main Methods:
- Review of current literature on olfactory tests.
- Discussion of clinical applications and diagnostic utility.
Main Results:
- Olfactory tests, particularly odour identification, are valuable diagnostic tools.
- Olfactory dysfunction can be an early biomarker for neurodegenerative diseases.
Conclusions:
- Olfactory testing plays a complementary role in diagnosing and managing neurodegenerative diseases.
- An Ear, Nose, and Throat (ENT) evaluation is essential prior to olfactory test administration.
- Self-administration of olfactory tests is discouraged.
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