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Updated: Aug 12, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
Viral evasion of the MHC class I antigen-processing machinery
1Institute of Biochemistry, Biocentre, J.W. Goethe-University Frankfurt, Marie-Curie-Str. 9, 60439 Frankfurt am Main, Germany.
Abstract:
In their adaptation to the immune system in vertebrates, viruses have been forced to evolve elaborate strategies for evading the host's immune response. To ensure life-long persistence in the host, herpes viruses, adenoviruses and retroviruses have exploited multiple cellular pathways for their purpose, including the class I antigen-processing machinery. Attractive and prominent targets for viral attacks are the proteasome complex, the transporter associated with antigen processing, and MHC class I molecules. This review briefly outlines the different mechanisms of viral interference with the antigen-presentation pathway.
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