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[The extracellular matrix and its regulation].

C M Lapière1, B V Nusgens

  • 1Laboratoire de Dermatologie Expérimentale, CHU Sart Tilman, Université de Liège, Belgique.

Pathologie-Biologie
|February 1, 1992
PubMed
Summary

The dermis, a connective tissue, relies on macromolecule networks for mechanical properties. Alterations in genes encoding these macromolecules can lead to connective tissue disorders.

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Area of Science:

  • Connective tissue biology
  • Molecular biology
  • Biochemistry

Context:

  • The dermis is a complex connective tissue.
  • Its mechanical properties are determined by a network of macromolecules.
  • This network includes glycoproteins and proteoglycans.

Purpose:

  • To describe the molecular basis of dermal mechanical properties.
  • To highlight the role of macromolecule interactions in cell function.
  • To connect genetic alterations to connective tissue disorders.

Summary:

  • Dermal mechanical properties arise from a network of polymeric macromolecules, including glycoproteins and proteoglycans.
  • These macromolecules possess recognition domains enabling self-association and binding to cell receptors.
  • Information transfer via this network, alongside cytokines and growth factors, regulates cell function.
  • The genetic basis and regulatory sequences for these macromolecules are well-understood.
  • Genetic alterations are implicated in various connective tissue disorders.

Impact:

  • Provides insight into the molecular underpinnings of tissue mechanics.
  • Establishes a link between molecular structure and cellular regulation.
  • Informs understanding of the etiology of connective tissue diseases.

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