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Comparative genomic hybridization in extramammary Paget's disease
1Pathology, Asan Medical Center, College of Medicine, University of Ulsan, 388-1 Poongnap-Dong, Songpa-Gu, Seoul 138-736, Korea. miumiu@www.amc.seoul.kr
The British Journal of Dermatology
|August 10, 2005
Summary
Genomic analysis of extramammary Paget's disease (EMPD) revealed chromosomal aberrations, including amplification and loss. Androgen receptor (AR) expression suggests a potential role in EMPD development.
Area of Science:
- Oncology
- Genetics
- Dermatology
Background:
- Extramammary Paget's disease (EMPD) is a rare skin cancer with an unclear origin.
- Limited data exists on chromosomal abnormalities in EMPD.
Purpose of the Study:
- To identify specific chromosomal aberrations in EMPD.
- To investigate the role of androgen receptor (AR) in EMPD.
Main Methods:
- Comparative genomic hybridization (CGH) was performed on 15 EMPD cases using pooled DNA.
- Immunohistochemistry was used to detect androgen receptor (AR) expression.
Main Results:
- Recurrent chromosomal changes identified include amplification at Xcent-q21 and 19, and loss at 10q24-qter.
- Androgen receptor (AR) expression was detected in six of the analyzed EMPD cases.
Conclusions:
- The findings suggest that androgen receptor (AR) may be implicated in the development of EMPD.
- Further research into AR signaling pathways in EMPD is warranted.