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Updated: Aug 16, 2026
Using a Laminating Technique to Perform Confocal Microscopy of the Human Sclera
Published on: May 6, 2016
Measurement of scleral thickness in uveal effusion syndrome
Andrew Lam1, Robert P Sambursky, Joseph I Maguire
1Retina Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. andrew.lam@aya.yale.edu
Purpose:
To measure scleral thickness in patients with and without uveal effusion syndrome using ultrasound biomicroscopy (UBM) and magnetic resonance imaging (MRI).
Design:
Prospective case-control study.
Methods:
UBM was used to measure scleral thickness in five subjects with uveal effusion syndrome and five matched controls. We also used MRI to measure scleral thickness in three subjects.
Results:
The mean thicknesses for eyes with uveal effusion syndrome versus control eyes were 0.65 +/- 0.08 mm and 0.55 +/- 0.05 mm, respectively (mean difference 0.10, P value = .13). MRI measurements of three subjects showed abnormally thick sclera but were imprecise.
Conclusions:
UBM can be used to measure scleral thickness, and our results support the finding that patients with uveal effusion syndrome have abnormally thick sclera. Compared with MRI, UBM may be a more accurate and precise method of measuring scleral thickness. UBM can be a useful adjunctive test in the management of uveal effusion syndrome.
