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Published on: June 2, 2014
Migraine and recurrent epistaxis in children
Imad T Jarjour1, Laila K Jarjour
1Department of Neurology, Allegheny General Hospital, Drexel University College of Medicine, Pittsburgh, Pennsylvania 1512, USA.
Insights
Recurrent nosebleeds (epistaxis) are significantly more common in children with migraine headaches. This study found a fourfold increased risk, suggesting a potential link and shared origins between these conditions in pediatric patients.
Area of Science:
- Pediatric Neurology
- Otolaryngology
- Genetics
Background:
- Recurrent epistaxis is a common pediatric issue with unclear causes.
- A potential link between epistaxis and migraine in children was observed.
Purpose of the Study:
- To investigate the association between recurrent epistaxis and migraine in children.
- To determine if epistaxis is a risk factor for developing migraine in pediatric populations.
Main Methods:
- A case-control study involving 45 children (ages 6-11) diagnosed with migraine.
- A control group of 64 children without recurrent headaches, matched for age and sex.
- Data collection via detailed questionnaires on medical history, including epistaxis and migraine prevalence.
Main Results:
- Children with migraine had a significantly higher prevalence of epistaxis (36%) compared to controls (11%).
- The odds ratio for epistaxis in children with migraine was 4.5 (P=0.002).
- Epistaxis onset typically preceded migraine by approximately 3 years, sharing characteristics with idiopathic epistaxis.
Conclusions:
- A significant association exists between recurrent epistaxis and migraine in children.
- Recurrent epistaxis may be a precursor or indicator for childhood migraine.
- Further longitudinal studies are needed to elucidate the shared pathogenesis of epistaxis and migraine.
Abstract:
Recurrent epistaxis is a common pediatric problem with uncertain etiology in most cases. We observed frequent complaints, or history of epistaxis in children with migraine. The aim of this study was to determine whether there is an association between epistaxis and migraine in children. A detailed questionnaire was used to conduct a study of 45 consecutive patients, ages 6-11 years, with migraine, diagnosed according to the 1997 proposed pediatric revisions to the International Headache Society criteria; the patients were evaluated in our Pediatric Neurology Clinic. Control subjects consisted of 64 children without recurrent headaches, matched as a group for age and sex, and drawn as a convenient sample from two general pediatric practices and an elementary school. Sixteen (36%) of 45 patients with migraine had epistaxis as compared with 7 (11%) of 64 control subjects (odds ratio = 4.5; 95% confidence interval 1.6-12.1; P = 0.002). Epistaxis began an average of 3 years before migraine with similar characteristics to idiopathic epistaxis in habitual nose-bleeders, such as onset in early childhood, high incidence in sleep, and family history of epistaxis. This study demonstrates a significant association between migraine and recurrent epistaxis in children. Recurrent epistaxis increased the odds of migraine more than fourfold. Moreover, these data raise the question of whether epistaxis may represent a precursor to childhood migraine. The two disorders may share a common pathogenesis, and a prospective, longitudinal study is required to define further the relationship between them.
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