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Acute endophthalmitis incidence: intravitreal triamcinolone
Andrew C Westfall1, Alexander Osborn, Derek Kuhl
1Department of Ophthalmology, Baylor College of Medicine, 6565 Fannin Street, Houston, TX 77030, USA.
Archives of Ophthalmology (Chicago, Ill. : 1960)
|August 10, 2005
Summary
Acute postinjection endophthalmitis after intravitreal injection of triamcinolone acetonide (IVTA) is uncommon. This study found a 0.10% incidence of culture-negative endophthalmitis in 1006 eyes receiving IVTA.
Area of Science:
- Ophthalmology
- Infectious Diseases
Background:
- Intravitreal injection of triamcinolone acetonide (IVTA) is a common treatment for various ocular conditions.
- Postinjection endophthalmitis is a rare but serious complication that can lead to vision loss.
Purpose of the Study:
- To determine the incidence of acute postinjection endophthalmitis following intravitreal triamcinolone acetonide injections performed as an office procedure.
Main Methods:
- A retrospective, noncomparative, consecutive, interventional case series was conducted.
- Data were collected from 1006 eyes that received IVTA at two clinical centers between January 2000 and January 2004.
Main Results:
- None of the 1006 eyes developed acute, culture-positive, postoperative endophthalmitis within six weeks of the procedure.
- One patient (0.10% incidence) developed acute, culture-negative, postoperative endophthalmitis four days after IVTA, presenting with decreased vision and conjunctival erythema without pain or hypopyon.
Conclusions:
- Acute postoperative endophthalmitis can occur following intravitreal triamcinolone acetonide injections.
- The incidence of this complication appears to be relatively uncommon based on this study's findings.