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Published on: May 17, 2024
Matrix metalloproteinases in cerebrovascular diseases
Marc Fatar1, Mark Stroick, Martin Griebe
1Department of Neurology, Klinikum Mannheim, University of Heidelberg, Mannheim, Germany. fatar@neuro.ma.uni-heidelberg.de
Abstract:
Matrix metalloproteinases are important factors for tissue remodelling and are activated during several physiological and pathological conditions, including cerebrovascular diseases. We give an overview of the structure, production and physiological effects of these widely distributed proteases and describe the genetic background and regulation pathways. In particular, we discuss the role of matrix metalloproteinases in vascular remodelling concerning ischaemic stroke, brain haemorrhage, vascular dementia, carotid artery plaques and cerebral aneurysms.
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