Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Implicit and explicit memory for spatial information in Alzheimer's disease.

R P C Kessels1, J Feijen, A Postma

  • 1Helmholtz Instituut, Utrecht University, Utrecht, The Netherlands. r.p.c.kessels@fss.uu.nl

Dementia and Geriatric Cognitive Disorders
|August 10, 2005
PubMed
Summary

Alzheimer's disease (AD) patients show impaired explicit spatial memory but intact implicit spatial memory. This suggests that spared implicit memory functions in AD may help compensate for explicit memory deficits.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural connectome and cognitive performance in young stroke survivors.

Scientific reports·2026
Same author

Corrigendum to "Systemic inflammation relates to neuroaxonal damage associated with long-term cognitive dysfunction in COVID-19 patients" [Brain Behav. Immun. 117 (2024) 510-520].

Brain, behavior, and immunity·2024
Same author

Systemic inflammation relates to neuroaxonal damage associated with long-term cognitive dysfunction in COVID-19 patients.

Brain, behavior, and immunity·2024
Same author

Gastrointestinal and eating problems in SCN1A-related seizure disorders.

Epilepsy & behavior : E&B·2023
Same author

Tensile properties of segmented block copolymers with monodisperse hard segments.

Journal of materials science·2021
Same author

Impaired Knowledge of Social Norms in Dementia and Psychiatric Disorders: Validation of the Social Norms Questionnaire-Dutch Version (SNQ-NL).

Assessment·2021

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Gerontology

Background:

  • Memory impairment in Alzheimer's disease (AD) primarily affects explicit, conscious memory, while implicit, unconscious memory remains relatively preserved.
  • Studies on spatial memory in AD indicate deficits in explicit spatial memory, potentially due to hippocampal dysfunction, but implicit spatial memory has been under-investigated.

Purpose of the Study:

  • To investigate both implicit and explicit spatial memory functions in patients with Alzheimer's disease (AD).
  • To determine if implicit spatial memory is also impaired in AD or if it remains relatively intact, similar to other implicit memory forms.

Main Methods:

  • Employed an ecologically valid computer-based task to assess spatial memory in 18 AD patients and 21 healthy controls.
  • Utilized the process dissociation procedure to differentiate and estimate the contributions of implicit and explicit memory functions.

Related Experiment Videos

Main Results:

  • Alzheimer's disease patients demonstrated significant impairment in explicit spatial memory compared to the control group.
  • No significant difference was observed between AD patients and controls in implicit spatial memory function.

Conclusions:

  • The findings indicate that spared implicit memory function in Alzheimer's disease extends to the spatial domain.
  • Explicit spatial memory deteriorates in AD, highlighting a potential therapeutic avenue where intact implicit memory could aid in managing cognitive challenges.