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Transforming growth factor beta(2) increases in subretinal fluid in rhegmatogenous retinal detachment with subretinal
Kumiko Hirase1, Tetsuya Sugiyama, Tsunehiko Ikeda
1Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Purpose:
To compare transforming growth factor (TGF) beta(2) levels in subretinal fluid of rhegmatogenous retinal detachment with or without subretinal strand formation.
Methods:
We assessed total and mature TGF-beta(2) levels in subretinal fluid obtained from 24 eyes with rhegmatogenous retinal detachment using an enzyme-linked immunosorbent assay. Group I comprised 18 specimens from eyes without subretinal strands, while group II comprised 6 specimens from eyes with subretinal strands.
Results:
Total and mature TGF-beta(2) levels were higher in group II than in group I (p=0.01 and p=0.07, respectively).
Conclusion:
The concentrations of total and mature TGF-beta(2) were higher in cases of rhegmatogenous retinal detachment associated with subretinal strand formation compared to those without subretinal strand formation.
