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Related Experiment Videos

Candidiasis in the intensive care unit.

J D Sobel1, J Vazquez

  • 1Department of Internal Medicine, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan, USA. jsobel@intmed.wayne.edu

Seminars in Respiratory and Critical Care Medicine
|August 10, 2005
PubMed
Summary
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Candida parapsilosis Vaginal Infection-a New Site of Azole Drug Resistance.

Current infectious disease reports·2018

Candida infections are a growing threat in intensive care units (ICUs). New antifungal treatments offer strategic responses to rising drug resistance in Candida species.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Candida species have emerged as significant opportunistic pathogens in intensive care units (ICUs).
  • Nosocomial infections caused by Candida are increasingly prevalent, particularly in critically ill patients.
  • Superficial candidiasis can be refractory to standard antifungals, while invasive infections carry high mortality rates.

Purpose of the Study:

  • To review the evolving landscape of Candida infections in ICUs.
  • To highlight the challenges posed by non-albicans Candida species and antifungal resistance.
  • To discuss emerging therapeutic strategies for invasive candidiasis.

Main Methods:

  • Literature review of epidemiological trends in Candida infections.

Related Experiment Videos

  • Analysis of antifungal susceptibility patterns.
  • Evaluation of current and novel treatment options for invasive candidiasis.

    • Main Results:

    • Increasing incidence of Candida infections in ICUs, with a rise in non-albicans species.
    • Emerging resistance to azole antifungals in certain Candida strains.
    • Development of effective treatments including lipid formulations of amphotericin B and echinocandins.

    Conclusions:

    • Invasive candidiasis in ICUs presents significant therapeutic challenges due to increasing incidence and antifungal resistance.
    • Lipid formulations of amphotericin B and echinocandins provide crucial treatment options.
    • Continued surveillance and development of new antifungal agents are essential for managing Candida infections.