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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Antibiotic resistance in hospitals and intensive care units: the problem and potential solutions

Robert A Weinstein1

  • 1Division of Infectious Diseases-129 Durand, Cook County Hospital, Cook County Bureau of Health Services, Chicago, Illinois 60612, USA. rweinste@rush.edu

Seminars in Respiratory and Critical Care Medicine
|August 10, 2005
PubMed

Insights

Antimicrobial resistance is rising due to bacterial genetics, antibiotic use, and poor hygiene. Effective interventions include hygiene measures, restricted antibiotic use, and surveillance cultures for resistant strains.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Public Health

Background:

  • Antimicrobial resistance has escalated over five decades, with temporary improvements after new drug classes.
  • Key drivers include bacterial genetic changes, antibiotic selection pressure, and inadequate hospital hygiene practices.

Purpose of the Study:

  • To review the trends in antimicrobial resistance.
  • To identify effective interventions for combating antimicrobial resistance.
  • To outline necessary strategies for managing resistant strains.

Main Methods:

  • Literature review of antimicrobial resistance trends and interventions.
  • Analysis of factors contributing to resistance development.
  • Evaluation of current and proposed control strategies.

Main Results:

  • Alcohol-based hand rubs and universal gloving are promoted hygiene solutions.
  • Antibiotic stewardship programs and provider computer-order entry show effectiveness.
  • Surveillance cultures and contact precautions are crucial for managing resistant organisms.

Conclusions:

  • Sustained efforts in hygiene, antibiotic stewardship, and patient management are essential.
  • Addressing antimicrobial resistance requires a multi-faceted approach.
  • Continued vigilance and implementation of evidence-based interventions are critical to curb resistance.

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