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Cardiovascular abnormalities in sleep-disordered breathing.

Brooke G Judd1, Stephen Liu, Michael J Sateia

  • 1Sleep Disorders Center, Dartmouth Medical School, Hanover, New Hampshire, USA. Brooke.G.Judd@Dartmouth.edu

Seminars in Respiratory and Critical Care Medicine
|August 10, 2005
PubMed
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Sleep-disordered breathing (SDB) may contribute to pulmonary hypertension (PH) and cor pulmonale, but its role is debated. While obesity and lung disease are primary drivers, SDB alone might cause some PH, though clinical impact is uncertain.

Area of Science:

  • Cardiology
  • Pulmonology
  • Sleep Medicine

Background:

  • Persistent pulmonary hypertension (PH) and cor pulmonale are serious conditions.
  • The link between sleep-disordered breathing (SDB) and these conditions is not well understood.
  • Previous studies have not extensively investigated this relationship.

Purpose of the Study:

  • To review the physiological cardiovascular changes during SDB.
  • To examine the current literature on the association between SDB and PH/cor pulmonale.
  • To clarify the role of SDB in the development of PH and cor pulmonale.

Main Methods:

  • Literature review of physiological changes during SDB.
  • Systematic review of recent studies on SDB, PH, and cor pulmonale.

Related Experiment Videos

  • Analysis of the impact of obesity and lung disease on PH in SDB patients.

    • Main Results:

    • SDB can cause cardiovascular changes.
    • Obesity and underlying lung disease are major contributors to PH in SDB.
    • Obstructive sleep apnea, as a form of SDB, may independently cause a small but significant degree of PH.

    Conclusions:

    • The contribution of SDB to PH and cor pulmonale is complex and multifactorial.
    • While SDB can play a role, it is often intertwined with other conditions like obesity and lung disease.
    • Further research is needed to determine the clinical significance of SDB-induced PH.