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Drug-induced lung disease: a pragmatic classification incorporating HRCT appearances
Jeffrey L Myers1, Andrew H Limper, Stephen J Swensen
1Division of Anatomic Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA. myers.jeffrey@mayo.edu
Seminars in Respiratory and Critical Care Medicine
|August 10, 2005
Summary
Recognizing common radiological and histopathologic patterns aids in diagnosing drug-induced lung disease. This framework helps differentiate drug effects from other lung conditions, improving patient management.
Area of Science:
- Pulmonology
- Radiology
- Pathology
Background:
- Drug-induced lung disease presents diagnostic challenges.
- Radiological and histopathologic patterns are key to diagnosis.
- Cytotoxic chemotherapy agents are common causes of diffuse lung disease.
Purpose of the Study:
- To outline a framework for understanding radiological and histologic patterns of drug-induced lung disease.
- To facilitate the diagnosis and management of drug-induced lung disease.
Main Methods:
- Review of common radiological patterns of drug-induced lung disease.
- Correlation of radiological findings with histopathologic diagnoses.
- Categorization of drug-induced lung disease into diffuse and chronic forms.
Main Results:
- Diffuse drug-induced lung disease can mimic acute respiratory distress syndrome and diffuse alveolar hemorrhage.
- Chronic forms include interstitial pneumonias, bronchiolitis obliterans organizing pneumonia, and eosinophilic pneumonia.
- Nonspecific patterns like organizing pneumonia and eosinophilic pneumonia can mimic idiopathic disease or neoplastic disease.
Conclusions:
- A systematic framework aids in diagnosing drug-induced lung disease.
- Understanding patterns helps differentiate drug toxicity from other lung pathologies.
- Early recognition and diagnosis are crucial for effective patient management.