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Related Experiment Videos

Respiratory bronchiolitis-associated interstitial lung disease.

Athol U Wells1, Andrew G Nicholson, David M Hansell

  • 1Interstitial Lung Disease Unit, Royal Brompton Hospital, London, England. a.wells@rbh.nthames.nhs.uk

Seminars in Respiratory and Critical Care Medicine
|August 10, 2005
PubMed
Summary
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Respiratory bronchiolitis-associated interstitial lung disease (RBILD) is an exaggerated response to smoking. Diagnosis relies on disease severity, clinical signs, and HRCT findings, distinguishing it from other lung conditions.

Area of Science:

  • Pulmonology
  • Radiology
  • Pathology

Background:

  • Respiratory bronchiolitis-associated interstitial lung disease (RBILD) is linked to cigarette smoke exposure.
  • RBILD shares features with respiratory bronchiolitis, necessitating clear diagnostic criteria.

Purpose of the Study:

  • To delineate RBILD as a distinct entity from desquamative interstitial pneumonia.
  • To outline diagnostic criteria and management considerations for RBILD.

Main Methods:

  • Histological examination of lung tissue.
  • High-resolution computed tomography (HRCT) imaging.
  • Bronchoalveolar lavage (BAL) analysis.

Main Results:

  • RBILD shows pigmented macrophages, inflammatory infiltration, and fibrotic thickening.

Related Experiment Videos

  • HRCT reveals centrilobular micronodules, ground-glass opacities, and bronchial thickening.
  • Diagnosis often combines clinical, HRCT, and BAL findings; biopsy may be needed for atypical cases.

    • Conclusions:

    • RBILD is distinct from desquamative interstitial pneumonia despite overlapping features.
    • While smoking cessation may help, RBILD can persist but generally follows a benign course.