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Updated: Jun 22, 2026
10:01
Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
Published on: July 10, 2012
Prognostication in chronic obstructive pulmonary disease: implications for lung transplantation
1Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0360, USA. fmartine@umich.edu
Seminars in Respiratory and Critical Care Medicine
|August 10, 2005
Summary
Lung transplantation offers survival benefits for patients with chronic obstructive pulmonary disease (COPD). For high-risk COPD patients, lung transplantation remains a viable treatment option.
Area of Science:
- Pulmonology
- Thoracic Surgery
- Transplantation Medicine
Background:
- Chronic obstructive pulmonary disease (COPD) is a leading indication for lung transplantation.
- Recent data indicate improved survival for COPD patients post-transplantation compared to other diagnoses.
- Questions arise regarding the comparative survival benefits and appropriateness of lung transplantation for COPD.
Purpose of the Study:
- To evaluate the survival advantage of lung transplantation in COPD patients.
- To determine if lung transplantation is appropriate for COPD patients compared to alternative treatments.
- To identify high-risk COPD patients who may benefit from transplantation.
Main Methods:
- Review of available clinical, physiological, and radiographic data.
- Analysis of survival outcomes in COPD patients undergoing lung transplantation.
- Comparison of transplantation outcomes with alternative therapies for advanced COPD.
Main Results:
- Lung transplantation demonstrates a favorable survival advantage for COPD patients.
- Clinical, physiological, and radiographic features can identify COPD patients with high mortality risk.
- Maximal medical therapy may not be sufficient for all advanced COPD patients.
Conclusions:
- Lung transplantation is a viable therapeutic option for selected high-risk COPD patients.
- Accurate prediction of survival in advanced COPD is challenging.
- Transplantation may offer improved survival for specific COPD populations.
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