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Related Experiment Videos

Chronic allograft rejection (obliterative bronchiolitis).

G M Verleden1

  • 1University Hospital Gasthuisberg, Department of Respiratory Medicine, Lung Transplantation Unit, Leuven, Belgium. geert.verleden@uz.kuleuven.ac.be

Seminars in Respiratory and Critical Care Medicine
|August 10, 2005
PubMed
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Chronic rejection, known as obliterative bronchiolitis (OB), remains a major obstacle to long-term survival after lung and heart-lung transplantation. This review covers current knowledge on OB pathophysiology and the bronchiolitis obliterans syndrome (BOS) grading system.

Area of Science:

  • Transplantation immunology
  • Pulmonary medicine
  • Surgical pathology

Background:

  • Lung and heart-lung transplantation offer effective treatment for end-stage lung disease.
  • Improved short-term survival rates are still limited by chronic rejection.
  • Obliterative bronchiolitis (OB) is the histological hallmark of chronic lung allograft rejection.

Purpose of the Study:

  • To review the current understanding of chronic rejection following lung and heart-lung transplantation.
  • To discuss the pathophysiology of obliterative bronchiolitis (OB).
  • To outline the clinical grading system for bronchiolitis obliterans syndrome (BOS).

Main Methods:

  • Literature review of studies on chronic rejection after lung and heart-lung transplantation.

Related Experiment Videos

  • Analysis of histological findings in obliterative bronchiolitis (OB).
  • Evaluation of the clinical diagnostic criteria for bronchiolitis obliterans syndrome (BOS).

    • Main Results:

    • Chronic rejection, manifesting as OB, leads to airway obstruction and declining pulmonary function.
    • Research is ongoing to elucidate the pathophysiology of OB and identify key molecular players.
    • The bronchiolitis obliterans syndrome (BOS) provides a clinical framework for assessing rejection severity.

    Conclusions:

    • Obliterative bronchiolitis (OB) significantly impacts long-term survival after lung transplantation.
    • Accurate diagnosis and grading of BOS are crucial for patient management.
    • Further research into OB pathophysiology may lead to improved therapeutic strategies.