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Related Experiment Videos

Venous thromboembolism: past, present and future.

J G Weg1

  • 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, USA. jweg@umich.edu

Seminars in Respiratory and Critical Care Medicine
|August 10, 2005
PubMed
Summary

Despite advances in diagnosing and treating venous thromboembolism (VTE), including pulmonary embolism (PE) and deep venous thrombosis (DVT), many patients remain undiagnosed. Improved patient history assessment and biological markers are needed to enhance VTE detection rates.

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Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Diagnostic Imaging

Background:

  • Significant progress in venous thromboembolism (VTE) diagnosis and treatment over four decades.
  • Transition from no objective documentation to advanced imaging studies for VTE detection.
  • Reduced mortality for pulmonary embolism (PE) to approximately 2% with evolving treatments.

Purpose of the Study:

  • To highlight the critical need for improved patient history in identifying VTE.
  • To emphasize the ongoing challenge of undiagnosed VTE cases despite advancements.
  • To advocate for the development of biological markers for VTE detection.

Main Methods:

  • Review of diagnostic and treatment advancements in VTE over the past 40 years.
  • Analysis of current trends in PE mortality and hospitalization.

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  • Discussion on the role of primary prophylaxis and patient history in VTE identification.

    • Main Results:

    • VTE diagnosis and treatment have seen remarkable improvements.
    • PE mortality has decreased to about 2%, with shorter hospitalizations and outpatient therapy becoming common.
    • Despite progress, a significant number of VTE patients remain undiagnosed, highlighting diagnostic gaps.

    Conclusions:

    • Further improvements in identifying patients who require objective VTE testing are essential.
    • Wider implementation of primary prophylaxis for VTE is encouraged.
    • The development of a specific biological marker for VTE is highly desirable for accurate and timely diagnosis.