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From alcohol toxicity to treatment
Helmut K Seitz1, Mikko Salaspuro, Markku Savolainen
1Department of Medicine, Salem Medical Center and Laboratory of Alcohol Research, Liver Disease and Nutrition, Heidelberg, Germany. helmut_karl.seitz@urz.heidelberg.de
Alcoholism, Clinical and Experimental Research
|August 10, 2005
Summary
This symposium explored alcohol
Area of Science:
- Biomedical Research
- Alcoholism Studies
- Gastroenterology
- Hepatology
- Carcinogenesis
Background:
- Symposium proceedings honoring Charles S. Lieber's 50 years in alcohol research.
- Focused on alcohol's effects on the gastrointestinal tract and liver.
- Highlighted recent discoveries in alcohol-associated carcinogenesis.
Framework:
- Acetaldehyde's role in alcohol-associated cancer pathogenesis.
- Genetic risk factors (ADH1C*1 allele) for upper aerodigestive tract cancer.
- Phosphatidylethanol as a bioactive lipid mediating alcohol's effects.
Implementation:
- Analysis of hepatic transcriptome in alcoholic liver disease.
- Identification of genes involved in alcohol-initiated liver fibrogenesis.
- Mechanisms of hepatocyte survival in cholestatic liver disease.
Implications:
- Understanding alcohol metabolism via the hepatic microsomal ethanol oxidizing system.
- Current status and treatment of alcoholic hepatitis.
- Pathophysiology of alcoholic liver disease as a basis for improved therapies.