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[Effect of yisui shengxue granule on gene expression in children with beta-thalassemia]
Li-min Chai1, Zhi-kui Wu, Xin-hua Zhang
1Department of Molecular Biology, Guang' anmen Hospital, China Academy of Traditional Chinese Medicne, Beijing
Objective:
To investigate the mechanism of yisui shengxue granule (YSG) in children with betathalassemia.
Methods:
The changes of hemoglobin (Hb), red blood cells (RBC), reticulocyte (Ret) and fetal hemoglobin (HbF) of 20 children with beta-thalassemia were measured before and after treatment. The effect of YSG on gene expression in myelo-karyocytes in 3 selected children treated effectively by YSG was determined by using DDRT-PCR.
Results:
The hematologic parameters were significantly enhanced and the ferritin gene expression declined after treatment respectively, as compared with those before treatment, the difference were significant (P < 0.01 or P < 0.05).
Conclusion:
YSG could improve the clinical symptoms of children with beta-thalassemia. One of its therapeutic mechanisms may be its action in decreasing ferritin gene expression so as to effectively relieve the accumulation of iron in body.
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