Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Olanzapine-induced vasculitis.

Mahesh K Duggal1, Amritpal Singh, Arunabh

  • 1Department of Geriatric Medicine, Wills Memorial Hospital, Washington, Georgia 30673, USA. mkduggal@nu-z.net

The American Journal of Geriatric Pharmacotherapy
|August 11, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Abstract Cognition Across Cultures.

Topics in cognitive science·2026
Same author

Predicting drug-target interactions and binding affinity using an optimized deep learning approach.

Journal of computer-aided molecular design·2026
Same author

Ten-year long-term survivors of blastic plasmacytoid dendritic cell neoplasm (BPDCN).

Leukemia & lymphoma·2026
Same author

Development and Evaluation of a PEGylated Lyophilized Nanoliposomal Formulation of Nilotinib for Enhanced Solubility, Intestinal Permeation, and In Vitro Anticancer Activity.

Asia-Pacific journal of clinical oncology·2026
Same author

Healthcare System Factors Affecting Preoperative Evaluation and Surgical Conversion in Adult Cochlear Implant Candidates.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery·2026
Same author

Unveiling the Unprecedented Optical Properties of Citrate-Stabilized Hollow AgAu Nanoshells Under Photothermal Irradiation.

Small science·2026
Same journal

Atypical antipsychotic use and parkinsonism in dementia: effects of drug, dose, and sex.

The American journal of geriatric pharmacotherapy·2012
Same journal

Use of rivastigmine or galantamine and risk of adverse cardiac events: a database study from the Netherlands.

The American journal of geriatric pharmacotherapy·2012
Same journal

Use of warfarin therapy among residents who developed venous thromboembolism in the nursing home.

The American journal of geriatric pharmacotherapy·2012
Same journal

Warfarin-antibiotic interactions in older adults of an outpatient anticoagulation clinic.

The American journal of geriatric pharmacotherapy·2012
Same journal

Effect of combination fluticasone propionate and salmeterol or inhaled corticosteroids on asthma-related outcomes in a Medicare-eligible population.

The American journal of geriatric pharmacotherapy·2012
Same journal

Dementia and risk of adverse warfarin-related events in the nursing home setting.

The American journal of geriatric pharmacotherapy·2012
See all related articles

Elderly patients on olanzapine may develop leukocytoclastic vasculitis, a rare but serious adverse drug reaction. Prompt recognition and discontinuation of olanzapine are crucial for managing this condition.

Area of Science:

  • Geriatric Medicine
  • Pharmacology
  • Dermatology

Background:

  • Elderly individuals are susceptible to adverse drug reactions due to polypharmacy and age-related metabolic changes.
  • Olanzapine is frequently prescribed for behavioral disturbances in elderly patients with dementia or delirium.

Observation:

  • A case report details an 82-year-old woman treated with olanzapine for agitated delirium.
  • The patient developed erythematous skin lesions, progressing to palpable purpura, consistent with vasculitis.
  • Skin biopsy confirmed leukocytoclastic vasculitis, with symptoms resolving upon olanzapine discontinuation and recurring upon re-challenge.

Findings:

  • Leukocytoclastic vasculitis is an infrequent but significant adverse drug reaction associated with olanzapine use.
  • The pathogenic mechanism involves immune responses, though not fully elucidated.

Related Experiment Videos

  • Diagnosis requires a high index of suspicion due to clinical and pathological similarity to idiopathic vasculitis.

    • Implications:

    • Clinicians must be vigilant for olanzapine-induced leukocytoclastic vasculitis in elderly patients.
    • Careful medication management, including monitoring for new drug reactions and de-prescribing unnecessary medications, is essential in this population.