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Cortisol in alcoholics with a disordered aggression control.

L Buydens-Branchey1, M H Branchey

  • 1Department of Psychiatry, Mount Sinai School of Medicine, City College of New York, New York City.

Psychoneuroendocrinology
|January 1, 1992
PubMed
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Individuals with severe violent behavior and alcoholism show elevated cortisol levels, suggesting dysregulated hypothalamic-pituitary-adrenal (HPA) axis function. This HPA axis dysfunction persists after alcohol cessation.

Area of Science:

  • Neuroendocrinology
  • Psychiatry
  • Addiction Medicine

Background:

  • The hypothalamic-pituitary-adrenal (HPA) axis is implicated in depression and aggression.
  • HPA axis function in individuals with aggression regulation disorders is understudied.
  • Aggressive behavior is frequently correlated with heavy alcohol consumption.

Purpose of the Study:

  • To investigate the HPA axis function in alcoholics with a history of violence.
  • To compare HPA axis function between alcoholics with depression, those with violent behavior, and controls.

Main Methods:

  • Basal 0700h cortisol levels were measured over 4 weeks in alcoholics post-cessation.
  • Participants included alcoholics with depression and those with a history of violent behavior (some incarcerated).

Related Experiment Videos

  • Cortisol levels were compared against alcoholics without mood or aggression regulation issues.

    • Main Results:

    • Alcoholics incarcerated for violent acts exhibited significant cortisol increases compared to other groups.
    • This cortisol elevation persisted for 4 weeks after alcohol cessation.
    • Alcohol consumption, benzodiazepine use, and liver function tests did not correlate with cortisol levels.

    Conclusions:

    • Severe violent behavior in alcoholics may be linked to dysregulated HPA axis function.
    • Alcohol abuse may reveal underlying HPA axis dysfunction in individuals with a history of severe violence.
    • Further research is warranted to explore the HPA axis in violent populations.