Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

From DNA sequence analysis to modeling replication in the human genome.

E B Brodie Of Brodie1, S Nicolay, M Touchon

  • 1Laboratoire Joliot-Curie (CNRS), Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.

Physical Review Letters
|August 11, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Herbal bitters in routine integrative care: a real-world prescription database study from a Swiss hospital.

BMC complementary medicine and therapies·2026
Same author

PULMONARY NODULE DETECTION IN CHEST CT USING A DEEP LEARNING-BASED RECONSTRUCTION ALGORITHM.

Radiation protection dosimetry·2021
Same author

Lesion detection on a combined "All-in-One" window compared to conventional window settings in thoracic oncology chest CT examinations.

Diagnostic and interventional imaging·2019
Same author

Vague abdominal pain after Roux-en-Y gastric bypass: not always an internal herniation: case report and literature review.

Acta chirurgica Belgica·2019
Same author

The Endovascular Treatment of Epistaxis.

Journal of the Belgian Society of Radiology·2018
Same author

High-resolution-scanning waveguide microscopy: spatial refractive index and topography quantification.

Optics letters·2017

Scientists modeled nucleotide compositional strand asymmetries in human chromosomes, revealing characteristic serrated skew profiles. This model identified 287 potential replication origins, crucial for understanding chromosome replication and stable nuclear structures.

Area of Science:

  • Genomics
  • Molecular Biology
  • Biophysics

Background:

  • Nucleotide compositional strand asymmetries are observed in genomes.
  • Replication origins are key regulatory sites for DNA replication.

Purpose of the Study:

  • To explore large-scale nucleotide compositional strand asymmetries along human chromosomes.
  • To model the characteristic serrated skew profiles observed.
  • To identify potential replication origins and their spacing.

Main Methods:

  • Analysis of nucleotide compositional strand asymmetries (skew).
  • Development of a replication model with defined origins and random terminations.
  • Identification of putative adjacent replication origins.

Related Experiment Videos

Main Results:

  • The (TA+GC) skew shows sharp upward jumps with linear decreasing profiles between replication origins.
  • A model accounting for replication origins and random terminations explains the observed serrated skew profiles.
  • 287 pairs of putative adjacent replication origins were identified with ~1-2 Mbp spacing.

Conclusions:

  • The identified replication origins likely correspond to replication foci.
  • These foci represent stable structures persisting across cell generations.
  • The model provides a framework for understanding chromosome replication dynamics.